2-Arylallyl as a new protecting group for amines, amides and alcohols.
نویسندگان
چکیده
Amines, amides and ethers containing 2-arylallyl groups are selectively and easily deprotected with tert-butyllithium. This transformation probably involves a carbolithiation reaction of the styrenyl moiety followed by a beta-elimination process.
منابع مشابه
Pd-catalyzed carbonyl insertion coupling reactions of a hypervalent iodoheterocycle with alcohols and amines.
The palladium-catalyzed cross-coupling carbonyl insertion reaction between 3,7-bis(N,N-dimethylamino)-10H-dibenz[b,e]iodinium iodide (1) and alcohols or amines 2 is described. Some new amides and esters 3 containing an active iodo functional group have been prepared in 65-91% yields.
متن کاملConversion of Alcohols into Amides Using Alumina-Methanesulfonic Acid (AMA) in Nitrile Solvents
The reaction of tertiary, secondary and benzylic alcohols with different nitriles in the presence of alumina-methanesulfonic acid (AMA) as a new reagent affords the corresponding amides in good yields (Table 1, 2). Conversion of 2,6-bis(hydroxymethyl)-4-halo anisoles into corresponding diamides in the range of 68-76% yields (Table 3) are also included in this paper.
متن کاملOne-pot synthesis of amides by aerobic oxidative coupling of alcohols or aldehydes with amines using supported gold and base as catalysts.
Synthesis of amides by aerobic oxidative coupling of alcohols or aldehydes with amines via intermediate formation of methyl esters is highly efficient and selective when using a catalytic system comprised of supported gold nanoparticles and added base in methanol.
متن کاملSubstitution of alcohols by N-nucleophiles via transition metal-catalyzed dehydrogenation.
Transition metal-catalyzed substitution of alcohols by N-nucleophiles (or N-alkylation of amines and related compounds with alcohols) avoids the use of alkylating agents by means of borrowing hydrogen (BH) activation of the alcohol substrates. Water is produced as the only by-product, which makes the "BH" processes atom-economic and environmentally benign. Diverse types of homogeneous organomet...
متن کاملDehydrogenative Synthesis of Imines from Alcohols and Amines Catalyzed by a Ruthenium N-Heterocyclic Carbene Complex
A new method for the direct synthesis of imines from alcohols and amines is described where hydrogen gas is liberated. The reaction is catalyzed by the ruthenium N-heterocyclic carbene complex [RuCl2(IiPr)(p-cymene)] in the presence of the ligand DABCO and molecular sieves. The imination can be applied to a variety of primary alcohols and amines and can be combined with a subsequent addition re...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Chemical communications
دوره 7 شماره
صفحات -
تاریخ انتشار 2005